Mutant Mice

BALB/c-Fox1nu/Ausb

• Origin – Imported from the University of New South Wales in 2008. This is an ABR substrain.
• Common name/s – BALB/c nude or nude
• Colour – White (het) or hairless (hom)
• Special characteristics – The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues. Tissues from the BALB/c nude can be transplanted onto normal BALB/c mice. The autosomal recessive nude gene in homozygous (nu/nu) mice causes the lack of fur and an abnormal thymus. Heterozygous (nu/+) animals carry the recessive nude gene on one chromosome only and therefore have a normal thymus triggered immune system.